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10.1124/mi.7.6.7 265 TraberM

Neferine exerts ferroptosis-inducing effect and antitumor effect on thyroid cancer through Nrf2/HO-1/NQO1 inhibition

In cancer, polyunsaturated fatty acids (PUFAs) have been shown to disrupt normal myelopoiesis in the bone marrow of tumor-bearing mice, leading to an increased accumulation and enhanced activity of PMN-MDSCs via the JAK/STAT3 signaling pathway [33]

In this perspective, we investigate the use of ROS-scavenging nanotechnology in ARD, discussing its safety, prospective uses, potential applications, and translational challenges in order to promote progress in the development of new treatments