In the absence of clinical pathological or histopathological effects, the NOAEL for systemic toxicity was 1000 mg/kg bw per day, the highest dose tested (Goldenthal, 1991)
1,911 View 87 Download Efficacy and safety of mirikizumab in maintenance therapy for ulcerative colitis in difficult-to-treat inflammatory bowel disease: a single-center retrospective study in Japan Ichiro Mizushima, Yusuke Yoshimatsu, Hiroki Kiyohara, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Yohei Mikami, Takanori Kanai Received August 13, 2025 Accepted November 19, 2025 Published online February 11, 2026 DOI: [Epub ahead of print] Abstract PDFSupplementary MaterialPubReaderePub Background/Aims Randomized controlled trials have confirmed the efficacy and safety of mirikizumab, an anti-interleukin-23p19 monoclonal antibody, for moderate-to-severe active ulcerative colitis (UC)
We specifically explore how genomic testing may be used in three primary radiotherapy applications for BM: patient stratification, early radiation treatment response monitoring, and selection of systemic therapies for use in combination with radiotherapy
Cytoplasmic Fe 2+ further activates the expression of iron-containing proteases on the mitochondrial membrane, and then transports cytoplasmic Fe 2+ into mitochondria, producing mitochondrial ROS and ferroptosis
Mercury in human hair as an indicator of the fish consumption