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Sliter et al

Gamma-glutamyltransferase and risk of cardiovascular disease mortality in people with and without diabetes: pooling of three British Health Surveys

Because prognostic factors are treatment dependent, improvements in therapy may diminish or abrogate the significance of any of these prognostic factors

Targeted inhibition of PTDSS1 expression results in increased ubiquitination of SLC3A2 and inhibition of GSH synthesis, thereby inducing oxidative stress in tumor cells, activating the PINK1/Parkin/MFN2 mitophagy pathway, and ultimately promoting tumor cell apoptosis and ferroptosis (Fig