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The remarkable phenomenon in animal models wherein widely different nutritional interventions in the mother (from global nutrient restriction to high-fat feeding) appear to result in the same metabolic syndrome phenotype in the offspring could also be explained by epigenetic perturbations in a small number of critical metabolic genes

A recent trial found that patients who receive rosiglitazone experience an earlier onset of heart failure, a higher risk of cardiovascular mortality, and a higher risk of hospitalization than patients in the control group who received glyburide