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After consideration of public comments on this proposed provision, we are finalizing our proposal as proposed at 427.302(d)

The primary role of RBP4 is to transport retinol (vitamin A) from the liver to peripheral tissues, where it is metabolized into retinoic acid ( Initially, research primarily linked RBP4 to obesity, insulin resistance (IR), and type 2 diabetes mellitus (T2DM) ( 2 RBP4 structure and function 2.1 RBP4 structural characteristics RBP4 is a single-polypeptide protein composed of 201 amino acid residues, with a molecular weight of approximately 21 kDa ( in vivo and link it closely to metabolic regulation and disease pathophysiology

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Table 3 shows that the most frequently used botanical drugs were Salvia miltiorrhiza Bunge (Danshen)