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This apparent contradiction may reflect a critical evolutionary adaptation in which cancer cells reprogram lactate metabolism to attain dual benefits (enhanced metabolic flexibility coupled with augmented oxidative stress resistance) thereby facilitating survival under adverse microenvironmental conditions

Glutaminolysis, mainly GLS activity, has been associated with (a) the accumulation of intracellular lipids by hepatocytes, 13 (b) HSC activation and fibrosis progression, 14,27 and (c) metabolic reprogramming that is needed to fuel cancer cell growth

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Extraction and cultivation of primary rat NPCs Ten SD rats (8 weeks old, male) were sacrificed with an overdose of 2% (w/v) pentobarbital sodium