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Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins

Elife 6

demonstrated that a hTERT-targeting Vx-001 vaccine, which included a TERT572Y cryptic peptide, improved clinical immune responses in the majority of NSCLC HLA-A2 + patients 118

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Yes, research in human muscle cell models shows that IGF-1 LR3 activates the Akt/mTOR pathway, increasing protein synthesis and myotube hypertrophy key markers of muscle growth and recovery