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In order to absorb B12 in the terminal ileum, the stomachs parietal cells produce a glycoprotein referred to as Intrinsic Factor (IF)

Conditions affecting any stage of this absorption pathwayincluding pernicious anaemia (an autoimmune condition destroying intrinsic factor-producing cells), Crohn's disease, coeliac disease, or surgical removal of stomach or ileal tissuecan significantly impair B12 absorption despite its water-soluble properties

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A word on injectable peptides A huge and largely unregulated market has emerged around injectable peptides, with most bought directly online - think longevity compounds, tanning agents, and recovery aids

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