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These postmortem results, along with those from the current and our previous study that highlighted a considerable number of differentially serum expressed amino acids between cases and controlsespecially in malessupport the idea that PD is a heterogeneous systemic disease that disrupts metabolic homeostasis across both central and peripheral organs (Costa et al., 2023)

Data S1 and S2)

Replenishing glutathione from dietary supplementation of Whey, N-Acetyl Cysteine, and Glutathione, are time- and dosedependant, but may further be inhibited by the influence of age, exercise stress, or environmental toxins

QTL significance was determined using logarithm of odds (LOD) scores, with a threshold of 7

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