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Gordon CA, Krause L, McManus DP, et al

According to Krithika Srikanthan et al., activation of the Na/K-ATPase signal cascade exacerbates obesity, diabetes, dyslipidemia, and atherosclerosis, and these conditions are all related to the imbalance of OS ( The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is closely related to antioxidant effects and is activated at the onset of OS ( Relationship Between Increased ROS Caused by Hyperglycemia and Cardiovascular Dysfunction Hyperglycemia (high levels of blood glucose) leads to increased production of ROS, which ultimately leads to vascular dysfunction ( Another question that needs resolution is how does high blood sugar level trigger OS and lead to cardiovascular dysfunction

Astragaloside IV (AIV), an active ingredient in Astragalus, helps to counteract ischemia-induced neuronal apoptosis and DNA damage by activating the Akt signaling pathway, protecting mitochondrial HK2, and reducing the release of pro-apoptotic proteins and AIF (191)

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In general, the efficient radiationless deactivating compounds are derivatives of benzophenone, substituted with hydroxyl and/or alkoxy groups, mostly in position(s) 2 and/or 4