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Ipamorelin works by: Binding to ghrelin receptors in the hypothalamus and pituitary Stimulating physiologic GH pulses Minimally impacting ACTH, prolactin, or cortisol, making it a well-tolerated option Enhancing IGF-1 levels downstream of GH Benefits Of Ipamorelin For Recovery 1

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Some peptides act directly on endocrine glands
Namely, BPC 157 is always applied alone (i.e., its own effect ascribed only to the peptide (for review, see Sikiric et al., 1993