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This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

If users saw no change in the first 14 days, they routinely bumped up their dose, switched injection sites, or questioned if their peptide was real

10.1038/s41392-022-00904-4 116 XieJ.BiY.ZhangH.DongS.TengL.LeeR

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The sooner we see what's actually happening in that tissue, the sooner we can do something about it