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When rupture occurs, the plaque exposes underlying pro-thrombotic substances, leading to platelet aggregation and thrombus formation, which are key processes in the pathogenesis of acute coronary syndromes, such as myocardial infarction and unstable angina

Dietary supplements are oral, but they have the same sort of regulatory scheme as the compounded drugs, in the sense that FDA can only intervene in them if they cause harm, as demonstrated, Woodcock said