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Future research should prioritize strategies that modulate GAM polarization, suppress MDSCs, and reinvigorate exhausted T cells to strengthen antitumor immunity and improve therapeutic outcomes

Significant inflammation with endotheliitis can lead to disseminated intravascular coagulation (DIC), and thrombosis of small and large vessels with tissue necrosis or infarction

The supplement requires the company to update its labeling to include the risk of thrombotic microangiopathy, in which blood clots may form in blood vessels, restricting blood flow and causing organ damage