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Notably, CA IX is highly expressed in peri-luminal areas in DCIS and is highly associated with necrosis and grade [60]

Fecal Lactobacillus mucosae NK41 and Bifidobacterium longum NK46 alleviate anxiety/depression and colitis by suppressing gut dysbiosis via downregulating hippocampal NF-B activation, BDNF expression, Iba1 + cell population, and blood corticosterone, IL- 6, TNF-, and LPS levels (Han and Kim, 2019)

Conclusion: While A1AT PI*MZ variant significantly increases the risk of liver related events in patients with non-lean NAFLD, it interestingly, did not seem to significantly increase the risk of developing hepatic events in patients with lean-NAFLD