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The In Vitro Cytotoxic Effect of Elesclomol on Breast Adenocarcinoma Cells Is Enhanced by Concurrent Treatment with Glycolytic Inhibitors

SOD serves as an antioxidant enzyme by catalyzing the conversion of superoxide anion to oxygen and hydrogen peroxide in the early stage of the catalytic process[52]

3,5-diCQM drives melanogenesis in a dose-dependent manner, and the molecular mechanism underlying its ability to induce pigmentation is through activation of the p38 signaling pathway, phosphorylation and activation of CREB, and a cAMP/PKA dependent signaling pathway, which in turn upregulates the transcription factor MITF, thereby activating tyrosinase activity (Kim et al., 2015)

Nature 261:166-168

The tubes were vortexed and incubated in the ultrasonic bath for 10 min then centrifuged at 13,000 rpm for 20 min at 4 C