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12 The de novo synthesis of NAD+ has been shown to enhance mitochondrial function, with enzymes like ACMSD playing a critical role in regulating cellular NAD+ levels and sirtuin activity

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The parallel investigations of clinical samples and animal models demonstrated that ALOX12 is also a predominant exacerbator of hepatic ischemia-reperfusion (I/R) injury but via disparate molecular mechanisms from that in NASH

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That said, human safety data currently consists of only three small studies with no randomized controlled trials, and the longest follow-up spans just 6 to 12 months