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Originally developed in the early 1990s by Professor Frank Ng and colleagues at Monash University in Australia, this peptide was engineered to isolate the lipolytic (fat-metabolizing) properties of growth hormone while eliminating its growth-promoting, diabetogenic, and IGF-1-stimulating effects

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Tirzepatides co-agonist activity leads to superior glucose-lowering and weight-loss effects compared to GLP-1 receptor agonists alone Muller, Nature Reviews Drug Discovery Originally developed by Eli Lilly and marketed under the brand name Mounjaro , tirzepatide was first approved by the FDA in 2022 for type 2 diabetes