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In 2015, the FDA addressed the concerns with a Safety Communication stating that it is safe and that the studies showing that it wasnt safe were all flawed.[ref] Lets take a look at some of the studies and then dig into the mechanism of action

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Promisingly, naturally derived compounds and synthetic chemicals exhibit such dual functionalities

Among these, Takeda G protein-coupled receptor 5 (TRG5) and FXR are the most extensively studied