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Inhibition of the AMPK/mTOR signaling pathway, activated markers related to autophagy (such as the ULK1 complex, Beclin-1, and LC3-II), an abnormal increase in autophagosomes and autophagolysosomes were detected in both PASMCs and PAECs when various types of PH models were constructed [84, 87, 88]

Via mitochondrial malfunction and ROS activation caused by bifurcating metabolic pathways (reverse electron transport and lipid metabolism), nicotinamide therapy promotes cancer cell death in TNBC in humans and mice (115) ( Table 2 )