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Cancer Commun (Lond) (2018) 38:12

Preclinical studies investigating KD in HD have primarily used transgenic mouse models, such as the R6/2 mice, which express mutant huntingtin and exhibit progressive motor deficits, weight loss, cognitive impairment, and mitochondrial dysfunction, mimicking central functional and metabolic aspects of HD progression [95, 96]

Thus, antioxidants surely can hinder oncogenesis by restoring redox balance, preventing DNA damage, regulating DNA methylation status, and repairing damaged DNA

Importantly, SCFAs regulate neuronal development and activity