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10.1016/j.nicl.2012.12.003 Neuroimage Clin

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Melanin is a pigment found in the skin responsible for the darkening of skin tone as it consists of blackish-brown eumelanin and reddish-yellowish pheomelanin

Subsequently, the antioxidant system is compromised, leading to the accumulation of lipid peroxides, which damages the cell membrane structure and ultimately results in cell death (Liu et al., 2022)