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Free Radic Biol Med 39:5849, PMID: 16085177 Richards RS, Roberts TK, Dunstan RH, McGregor NR, Butt HL (2000) Free radicals in chronic fatigue syndrome: cause or effect

However, with high or chronic levels of oxidative stress this effect gets much larger and the loss of cysteines is quite large

Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation

Weis et al

For example, NMR-titration experiments of non-glutathionylated poplar GrxC4 or ScGrx8 with GSH required high glutathione concentrations to detect chemical shifts 47,48 (and titrations of active site serine mutants with GSSG cannot discriminate between both glutathionyl moieties)