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These results, combined with the direct correlation of the expression levels of ELAVL1 with the genes of the malate-aspartate shuttle, as seen with the breast cancer transcriptome data, suggest that while citrate and malate are likely more dependent on KGA metabolism, fumarate and aspartate can be generated by glutamine metabolism from either isoform

doi: 10.7554/eLife.45051 233 SlavoffS

Knudsen et al

Additionally, many ME/CFS patients experience symptoms similar to bacterial or viral infections which may correlate to specific regions