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This trial evaluated the safety and tolerability of both single ascending doses and multiple ascending doses of Molgramostim in humans

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The major sensitivity of mitochondrial DNA to ROS-induced mutagenesis is intuitive, as this DNA is not protected by histones, and mitochondria lack the nucleotide excision repair (NER) enzymatic system

Maack C, Tardiff JC (2022) Targeted therapies for cardiac diseases

The CAR-T cells showed activation (for example, upregulation of CD40LG, IL-2RA and CSF2RB markers) even in the absence of tumor cells (Supplementary Fig