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By employing the safe and feasible gene-editing tool CRISPR/Cas9 to engineer T cells, this method can mitigate exhaustion-inducing signaling pathways, preserve antitumor activity, and increase the in vivo persistence of CAR-T cells, thereby further overcoming limitations in cancer therapy (Fig

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Drug-Induced Liver Injury Following a Repeated Course of Ketamine Treatment for Chronic Pain in CRPS Type 1 Patients: A Report of 3 Cases. 2011 Sep;152(9):2173-8