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Cobyrinic acid a,c-diamide production was monitored using LC-MS (see Analytical methods below)

Long-term use of NAC at therapeutic doses (3600mg daily) has been studied in the context of specific medical conditions without significant adverse effects, though this level of dosing should be supervised

Relationship of iron to oligodendrocytes and myelination

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Although endogenous synthesis partially compensates, supplementation may be relevant, particularly for vegan athletes, vegetarian seniors, or during caloric restriction periods