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Studies indicate that A1AT therapy can lead to a reduction in systemic inflammation, as measured by lower CRP levels, thus potentially decreasing the overall inflammatory burden on the lungs (68) Moreover, the reduction in inflammatory markers can also be indicative of the therapys effectiveness in mitigating the proteolytic damage caused by neutrophil elastase, which is typically unopposed in AATD patients due to low A1AT levels

The questions to achieve the objective of the SR ( Table 1 ) were formulated based on Population Intervention Comparison Results (PICOS) criteria ( Table 2 )

268 When activated, the vagus nerve can reduce the contraction of the stomach, thereby slowing down food emptying

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