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Semin Cell Dev Biol 98:3443 Mats JM, Segura JA, Alonso FJ, Mrquez J (2008) Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

This review highlights the therapeutic potential of individual natural compounds, as well as emerging strategies in combinatorial and precision medicine, offering a comprehensive synthesis of current advancements in natural product-based AD therapy

Copper-containing compounds carry documented toxicological considerations, and the parenteral route bypasses the physiological mechanisms that regulate copper absorption

Therefore, a comprehensive exploration and assessment should be performed to elucidate the relation behind each mechanism

Notably, compounding walnut peptide with ginseng saponin to feed senescence-accelerated mice (SAM) revealed that walnut peptide significantly increased the serum levels of antioxidant enzymes and reduced A and p-tau in the hippocampus through activation of the brain-derived neurotrophic factor (BDNF)/TrkB-dependent PI3K/Akt signalling pathway, significantly improving the memory of rats with neurodegenerative disease capacity (118)