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This translates geographically into a high incidence of these anemias in low and middle-income countries

However, three major translational barriers persist: (1) Safety concerns from systemic metabolic effectsIDO inhibitors failed to demonstrate survival benefits in phase III trials potentially due to autoimmune toxicity from excessive immune activation

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10.1021/acs.jafc.4c08428 99 LiuJ.LiuZ.LiX.ZhuL.XuG.ChenZ.et al (2020)