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2022;12:26335565221145461 Martinez-Velilla N

wherein Y295 is either an F, or W

In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)

doi: 10.1038/s41586-018-0316-7 123 FanYTanXZhaoHTuXLiuXWangY

Alternatively, stimulating FA re-esterification would be beneficial by preventing ER stress, mitochondrial damage and the lipotoxic effects of FAs (242, 243)