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Increased citrullination is not specific to RA and occurs regularly with any environmental stress, including in lung alveolar macrophages in cigarette smokers (6)

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

(2019) Serum Biotin and Zinc in Male Androgenetic Alopecia

Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)

The segment continues to gain traction due to on-the-go consumption trends