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Quantitative real-time PCR (RT-qPCR) analysis Using Trizol to extract the total RNA from liver tissues and cells

2004 Jun;9(2):157-79

Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011