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A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]

Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy

One drink early in the day is far less damaging than 2 to 3 drinks close to bedtime: timing matters more than total volume

Vial Options: 2 mg, 5 mg, or 10 mg vials with optimized reconstitution for each size

In this review, we attempt to crystallize these concepts and analyze the current evidence supporting the efficacy of glutathione as an inhibitor of melanization