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People with megaloblastic anemia need to be tested for vitamin B 12 deficiency before treatment with folic acid, because if the person has vitamin B 12 deficiency, folic acid supplementation can remove the anemia, but can also worsen neurologic problems

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Age & Sex Increased susceptibility to the pharmacologic or toxic activity of drugs has been reported in very young and old patients compared with young adults (see Chapters 60 and 61)