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Sadly, approximately 30% of patients develop Painful Diabetic Neuropathy (PDN) with neuropathic pain and symptoms like burning, needles, cold, or heat cramps, electric shock, weakness, and allodynia

Funding This research was supported by Scientific planning project of youth education in Shandong province Undergraduate Academic Project (23BSH251)

Identifier NCT06066515

Each batch is produced under controlled conditions and undergoes quality checks to confirm it meets our internal standards before being released

Third, although the protective effect of ISO against H 2 O 2 -induced oxidative damage in HaCaT cells was investigated in the present study, further experiments and collaborative discussions should be held to identify the effect of ISO on H 2 O 2 -induced melanocytes, which would improve the development of ISO as a source of antioxidants and provide a theoretical basis for the targeted therapy of vitiligo