Although the exact mechanism of canities subita is not yet fully understood, current evidence suggests a link between this condition and immune system dysregulation, particularly in autoimmune alopecia areata targeting melanocytes
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Of note is also that the supplementation with folic acid at doses higher than 1000 g/d was negatively associated with global verbal scores in children (Reference Valera-Gran, Navarrete-Muoz and Garcia de la Hera121)
The other is appearance-related interest, especially skin clarity and overall radiance
