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Additionally, SNRIs such as duloxetine exert their analgesic effect by enhancing serotonin (5-HT) and norepinephrine (NE)-mediated descending inhibitory systems in the spinal cord (Obata, 2017)

First isolated in the 1970s from the cerebral venous blood of sleeping rabbits, DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide whose biology has fascinated and puzzled neuroscientists for half a century

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based on the assessment of consumption of ASBs or tabletop sweetener packets containing aspartame only) and additionally subject to recall bias, which is inherent in the design of retrospective casecontrol studies