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Majzoub and the Lowell laboratory for helpful discussions

This dependency makes them vulnerable to pharmacological inhibition of mitochondrial respiration, and multiple related agents have already entered clinical use or advanced clinical trials [516, 520]

Precisely, superoxide anion and hydrogen peroxide have been reported to act as mitogens, thereby promoting the rate of DNA replication and cell proliferation in a variety of cultured cells.9, 10 Nonetheless, in excess amounts, oxygen-derived radicals are very harmful to living organisms