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Using the optogenetic-microdialysis method, an increase in the sensitivity of cortico-striatal terminals to release glutamate could be demonstrated in the rat with BID, since a lower frequency of optogenetic stimulation was necessary to induce striatal glutamate release as compared to controls ( 1 receptors (A 1 Rs) and a relative upregulation of adenosine A 2A receptors (A 2A Rs) (111, 112)

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