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Cingulin and ZOs are cytoskeletal linker proteins, which interact with the cytoplasmic peripheral membrane proteins, occludin, claudin, and JAM to form strong cross-links and interact with the membrane cytoskeleton composed of F-actin and myosin

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doi: 10.1021/acs.chemrev.9b00371

This supplementation is especially effective if the individual starts treatment before organ/tissue damage occurs To avoid low blood sugar, dextrose (a sugar) is given through intravenous administration