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Moreover, NHANES data indicate that less than 9% of pregnant women meet the AI for choline (106)

When T cells are modified to generate CAR-T cells, a unique mitochondrial adaptation is required to establish stemness and persistence of the CAR-T cells (279)

Importantly, in conditions where the affected tissue is directly involved in disease pathogenesis and can be easily obtained via minimally invasive biopsy, the power of this strategy increases substantially