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Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice

Perilipin ablation is associated with near-maximal rates of lipolysis under basal conditions (78)

A- Methylcobalamin is the active form of vitamin B12 with better nerve affinity and retention, while cyanocobalamin is synthetic and requires conversion in the body

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In the mitochondria, AMPK stimulates -oxidation which is the process of breaking down fatty acids into acetyl-CoA and consequently raises energy expenditure