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in these settings, ICA reduces intratumoral Treg infiltration and enhances CD8 + T cell cytotoxicity, even overcoming the inherent immunotherapy resistance of MSI-L tumors

These bacterial groups engage in metabolic interactions with butyrate-producing bacteria, forming a complex cross-feeding network (Figure 5)

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Eventually, aggregated proteins enter the amyloid state by polymerizing into linear structures with ordered cross-sheet connections (Fig

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