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Key distinction: BPC-157 is not a steroid, not a hormone, and not a growth hormone releasing peptide

The peptides ability to cross the blood-brain barrier and affect central nervous system tissue remains partially characterized but has generated interest in neurological applications

J Physiol Pharmacol 64:597612 Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P (2006) Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: promoted tendon-to-bone healing and opposed corticosteroid aggravation

Both animal and human studies indicate that MOTS-c levels tend to decline with advancing age in tissues like skeletal muscle and in circulation

Orthopaedic surgery is uniquely sensitive to small shifts in perioperative risk, particularly in implant-based procedures where complications carry disproportionate consequences