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The Crohns disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy

That, in itself, is a significant stride forward in the care of Ehlers-Danlos Syndrome.

The RNA-seq data generated in this study have been deposited in the Gene Expression Omnibus (GEO) database under accession codes GSE263190 and GSE263119

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Each has dramatically upended (one might say disrupted) a staid, inefficient industry and created enormous value by increasing transparency and dramatically reducing search and transaction costs for consumers in other words, by organizing previously complex and opaque industries into marketplaces that favor consumers