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Description

Typical subcutaneous dosing ranges from 1-3 mg daily or 3-5 times per week, often cycled in 8-12 week protocols with 4-week breaks to prevent receptor downregulation or copper accumulation

Nat Rev Endocrinol 9 , 346356 (2013)

That single change blocks the enzymes that would normally chew up the peptide, which is a large part of why such a small molecule is so potent at the mu-opioid receptor