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The added complexity and cost make them less suitable for general optimization purposes

Long-term safety of high-dose angiotensin receptor blocker therapy in hypertensive patients with chronic kidney disease

Proc Natl Acad Sci U S A 91:12614, PMID: 8108398 Kuchino Y, Mori F, Kasai H, Inoue H, Iwai S, Miura K, Ohtsuka E, Nishimura S (1987) Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

Effectiveness of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on total and cardiovascular mortality and morbidity in primary prevention: a nationwide study based on French health insurance data (SNDS)

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