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In this clinical trial 21 major surgical procedures comprising of 14 orthopedic, and 7 non-orthopedic procedures, and 5 additional minor surgeries were performed in 21 patients

Arch Gen Psychiatry (2001) 58:54553.10.1001/archpsyc.58.6.545 153 SchroeterMLAbdul-KhaliqHSacherJSteinerJBlasigIEMuellerK

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However, melatonins receptors can be Gq-coupled and activate phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2), producing inositol triphosphate (IP3) and 1,2-diacylglycerol (DAG), which increases Ca +2 levels and activates calmodulin (CaM) and CaM kinase signaling [158, 159]