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Altered renal proximal tubular endocytosis and histology in mice lacking myosin-VI

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Chem Rev 111 , 59445972 (2011)

System Xc - is composed of two subunits, a heterodimer consisting of a heavy chain subunit, SLC3A2, and a light chain subunit, SLC7A11, respectively ( - to uptake cystine into the cell, and the cystine entering the cell is reduced to cysteine, which is an important raw material for synthesizing glutathione (GSH)

Moreover, patients presenting with EZH2 overexpression showed a significantly lower survival rate compared to those having low EZH2 expression